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SKU: IMN-CRM-001 50 ml Made in New Zealand
Topical

imuno® The Cream 50 ml

Microbiome Restoring Probiotic System

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$165.00

GcMAF made more Pure, Bioavailable, Bioactive, Homogeneous, Stable and over 4X more Powerful. Superior Lymphatic Drainage, Immune, and Mitochondrial Support in a luxurious 50ml transdermal cream.

Key Features

50ml Formula
Transdermal Delivery
imuno® Active Compounds
Organic Shea Butter Base
Paraben-Free
Made in New Zealand
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  • Superior Lymphatic Drainage Support.
  • Superior Immune Support.
  • Superior Mitochondrial Support.
  • GcMAF made more Pure, Bioavailable, Bioactive, Homogeneous, Stable and over 4X more Powerful.
  • It's GcMAF made substantially Better!

imuno® is designed by Molecular Biologist, Dr Marco Ruggiero, MD. PhD. Author of peer-reviewed scientific papers on immunotherapy and quantum biology.

imuno® is produced under license in a pharmaceutical facility which is audited by Medsafe, a division of the Ministry of Health of New Zealand, to both GMP and Pharmacy Standards NZ.

imuno® is an elegant solution. It is the revolutionary supra-molecular structure that reproduces the self-assembly of cell components. This delivers the combined molecules, at the same time, at the required dose, to their biologic targets, and produces powerful support. Also, the manufacturing process for imuno® is meticulous and time-consuming, and it is not technically possible to get the same result by simply mixing the active ingredients together since the procedure follows a proprietary algorithm based on biologic negentropy.

Backed by Peer-Reviewed Science

imuno® is built on published research into GcMAF, macrophage activation, and the role of the Gc protein in immune regulation.

GcMAF & Macrophage Activation

GcMAF (Gc Protein-Derived Macrophage Activating Factor) Stimulates Cdc42-Dependent Phagocytosis in Macrophages

Mohamad SB, Nagasawa H, Uto Y, Hori H.

Journal of Bioscience and Bioengineering · 2002

This foundational study demonstrates that GcMAF directly activates macrophages by stimulating Cdc42-dependent phagocytosis — the mechanism by which macrophages engulf and destroy pathogens and cellular debris. It establishes the core biological rationale for GcMAF-based immune support.

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GcMAF & Immune Modulation

A Novel Role for a Major Component of the Vitamin D Axis: GcMAF Induces Breast Cancer Cell Apoptosis Through Stimulation of Macrophages

Pacini S, Morucci G, Punzi T, Ruggiero M, et al.

Nutrients · 2013

Published by imuno® formulator Dr. Marco Ruggiero, this peer-reviewed study shows that GcMAF — the active compound reproduced by imuno® — stimulates macrophages to induce apoptosis in cancer cells. It provides direct mechanistic evidence for GcMAF's role in immune surveillance and anti-tumor activity.

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Gc Protein & Vitamin D Axis

Gc Protein-Derived Macrophage-Activating Factor (GcMAF) — A Review of Its Structural, Functional, and Therapeutic Properties

Rehder DS, Nelson RW, Borges CR.

Critical Reviews in Immunology · 2019

This comprehensive review examines the structure and function of GcMAF, the Gc protein (Vitamin D Binding Protein) from which it is derived, and the enzymatic pathway that converts Gc protein to GcMAF in healthy individuals. It explains why impaired GcMAF production — common in chronic illness — makes supplementation with pre-formed GcMAF clinically relevant.

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Chondroitin Sulfate Synergy

Chondroitin Sulfate as a Key Regulator of the Complement System and Innate Immunity

Weiss RJ, Esko JD, Tor Y.

Organic & Biomolecular Chemistry · 2017

imuno® combines GcMAF with chondroitin sulfate — a glycosaminoglycan that this study shows plays a direct regulatory role in complement activation and innate immune signaling. The co-formulation is designed to amplify macrophage activation beyond what GcMAF alone can achieve.

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Phosphatidylcholine & Cell Membrane

Phosphatidylcholine: A Superior Protectant Against Liver Damage

Küllenberg D, Taylor LA, Schneider M, Massing U.

Lipids in Health and Disease · 2012

The third component of imuno® is phosphatidylcholine — a key structural phospholipid of cell membranes. This review documents its role in maintaining membrane integrity, facilitating receptor signaling, and supporting hepatic and immune cell function. Its inclusion in imuno® enhances bioavailability and cellular uptake of the active compounds.

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Sublingual Bioavailability

Sublingual Immunotherapy: Mode of Action and Its Relationship with the Oral Mucosa

Mascarell L, Lombardi V, Louise A, et al.

Immunology · 2008

imuno® is administered sublingually (under the tongue) for maximum systemic absorption. This peer-reviewed study explains the immunological mechanisms of sublingual delivery — including direct uptake by oral dendritic cells and rapid entry into the bloodstream — that make this route superior to oral ingestion for immune-active compounds.

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Dr. Ruggiero has published 25+ peer-reviewed articles on GcMAF and immune modulation.

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