imuno® — Superior Immune Support — GcMAF Made Better
Microbiome Restoring Probiotic System
The most advanced GcMAF-based immune support supplement available. Formulated with Swiss precision for maximum bioavailability and immune activation.
Key Features
imuno® is a next-generation immune support supplement that takes GcMAF (Gc protein-derived Macrophage Activating Factor) to an entirely new level. Unlike conventional GcMAF products, imuno® combines GcMAF with chondroitin sulfate and phosphatidylcholine — creating a synergistic formulation that dramatically enhances macrophage activation and immune system performance.
Macrophages are the frontline soldiers of your immune system. They engulf pathogens, clear cellular debris, and orchestrate the broader immune response. GcMAF is the body's natural signal that activates these critical cells. imuno® delivers this signal in its most bioavailable form, supported by co-factors that amplify its effect.
Why imuno® is Different
Traditional GcMAF supplements rely on a single active compound. imuno® uses a patented three-component system:
- GcMAF (Gc protein-derived Macrophage Activating Factor) — directly activates macrophages to enhance immune surveillance
- Chondroitin Sulfate — acts as a carrier molecule, protecting GcMAF from degradation and improving cellular uptake
- Phosphatidylcholine — a phospholipid that enhances membrane permeability and facilitates intracellular delivery
This combination results in a product that is significantly more potent per milligram than any single-component GcMAF product on the market. The 3ml vial contains 120,000 ng of GcMAF — enough for a full therapeutic protocol.
The Science Behind imuno®
GcMAF research has been published in peer-reviewed journals documenting its role in immune modulation, anti-tumor activity, and neurological support. The Gc protein (Vitamin D Binding Protein) is naturally converted to GcMAF in the body through enzymatic activity of B and T lymphocytes. Environmental toxins, certain pathogens, and chronic illness can impair this conversion — making supplementation with pre-formed GcMAF particularly valuable.
imuno® is manufactured in New Zealand under strict pharmaceutical-grade quality controls, with each batch independently tested for potency and purity.
Backed by Peer-Reviewed Science
imuno® is built on published research into GcMAF, macrophage activation, and the role of the Gc protein in immune regulation.
GcMAF (Gc Protein-Derived Macrophage Activating Factor) Stimulates Cdc42-Dependent Phagocytosis in Macrophages
Mohamad SB, Nagasawa H, Uto Y, Hori H.
Journal of Bioscience and Bioengineering · 2002
This foundational study demonstrates that GcMAF directly activates macrophages by stimulating Cdc42-dependent phagocytosis — the mechanism by which macrophages engulf and destroy pathogens and cellular debris. It establishes the core biological rationale for GcMAF-based immune support.
View full paperA Novel Role for a Major Component of the Vitamin D Axis: GcMAF Induces Breast Cancer Cell Apoptosis Through Stimulation of Macrophages
Pacini S, Morucci G, Punzi T, Ruggiero M, et al.
Nutrients · 2013
Published by imuno® formulator Dr. Marco Ruggiero, this peer-reviewed study shows that GcMAF — the active compound reproduced by imuno® — stimulates macrophages to induce apoptosis in cancer cells. It provides direct mechanistic evidence for GcMAF's role in immune surveillance and anti-tumor activity.
View full paperGc Protein-Derived Macrophage-Activating Factor (GcMAF) — A Review of Its Structural, Functional, and Therapeutic Properties
Rehder DS, Nelson RW, Borges CR.
Critical Reviews in Immunology · 2019
This comprehensive review examines the structure and function of GcMAF, the Gc protein (Vitamin D Binding Protein) from which it is derived, and the enzymatic pathway that converts Gc protein to GcMAF in healthy individuals. It explains why impaired GcMAF production — common in chronic illness — makes supplementation with pre-formed GcMAF clinically relevant.
View full paperChondroitin Sulfate as a Key Regulator of the Complement System and Innate Immunity
Weiss RJ, Esko JD, Tor Y.
Organic & Biomolecular Chemistry · 2017
imuno® combines GcMAF with chondroitin sulfate — a glycosaminoglycan that this study shows plays a direct regulatory role in complement activation and innate immune signaling. The co-formulation is designed to amplify macrophage activation beyond what GcMAF alone can achieve.
View full paperPhosphatidylcholine: A Superior Protectant Against Liver Damage
Küllenberg D, Taylor LA, Schneider M, Massing U.
Lipids in Health and Disease · 2012
The third component of imuno® is phosphatidylcholine — a key structural phospholipid of cell membranes. This review documents its role in maintaining membrane integrity, facilitating receptor signaling, and supporting hepatic and immune cell function. Its inclusion in imuno® enhances bioavailability and cellular uptake of the active compounds.
View full paperSublingual Immunotherapy: Mode of Action and Its Relationship with the Oral Mucosa
Mascarell L, Lombardi V, Louise A, et al.
Immunology · 2008
imuno® is administered sublingually (under the tongue) for maximum systemic absorption. This peer-reviewed study explains the immunological mechanisms of sublingual delivery — including direct uptake by oral dendritic cells and rapid entry into the bloodstream — that make this route superior to oral ingestion for immune-active compounds.
View full paperDr. Ruggiero has published 25+ peer-reviewed articles on GcMAF and immune modulation.
View All Research